The hla region encodes several molecules that play key roles in the immune system strong association between the hla region and autoimmune disease aid has been established for over fifty years. Human leukocyte antigen hla region of chromosome 6 the human leukocyte antigen hla system or complex is a gene complex antibodies against disease associated hla haplotypes have been proposed as a treatment for severe autoimmune diseases. The association between genetics particularly the genes of the major histocompatibility complex mhc and many autoimmune diseases has long been known even though the actual disease susceptibility genes or the mechanism that confers the disease often remain to be elucidatedhere we discuss a number of autoimmune and other inflammatory disease reviewing the prevalence and epidemiology where . The first human leukocyte antigen hla haplotype association with inflammatory disease was discovered in 1972 correlating hla b27 with ankylosing spondylitis this remains one of the strongest known associations of disease with hla b27. These subtypes are designated as hla b 2701 to hla b 2743 more than 100 diseases have been associated with different alleles of hla genes for example the hla b27 allele increases the risk of developing an inflammatory joint disease called ankylosing spondylitis many other disorders involving abnormal immune function and some forms of
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